One of the sources available in the South Carolina Room is the Greenville newspaper on microfilm dating from 1826. Significant news articles in the Greenville News concerning South Carolina and the upstate are indexed from 1991 to the present. The index is available at INNEWS. Also available from INNEWS are obituary and marriage indexes dating from 1994.

The South Carolina Room staff is available to assist researchers in person or through the Records Search Form.

South Carolina Birth Certificates and South Carolina Death Certificates began in 1915. The birth certificates have not been released to libraries as there is a one hundred year delay before they become public records. The death certificates are released with a fifty year delay. The microfilmed certificates from 1915 -1958 are available in the South Carolina Room. Also available on microfiche, is an index of death certificates from 1915-1957. The South Carolina Department of Health and Environmental Control provides an online index for all the years that have been released.

The Carolina First South Carolina Room has the Greenville County Marriage Licenses from 1911-1995 on microfilm. A searchable microfilm index is available at Greenville County Marriage Licenses Search.